We hope you don’t need it, but if you do, Laminil is available now in the US, Canada, Australia, and Dubai.

How Does Laminil Stop Laminitis?

Laminitis is an inflammatory response to stress. Laminil halts the inflammatory process. It’s simple and complex.

Like many diseases and conditions, laminitis occurs when an immune system response to stress goes wrong and starts a cascade of biochemical processes that cause inflammation and destruction of the foot. Mast cells play a key role in that cascade by releasing histamine and other inflammatory mediators, such as neutrophils, lymphocytes, and macrophages. These inflammatory agents, in turn, activate pro-inflammatory cytokines (cell-signaling proteins) that incite inflammation. Cytokines also inhibit growth factor receptors and the expression of genes involved in hoof growth and maturity. Thus, the inflammatory response both destroys cells and stops cell replacement.

Laminil is a mast cell inhibitor that intercepts the laminitis cascade at the mast cells and inhibits the release of histamine and other inflammatory mediators. By interrupting the inflammatory process at the mast cells, Laminil prevents continued release of inflammatory mediators and enables growth to resume.

Other equine products treat inflammation after it has occurred, which is good. Laminil halts the biochemical processes that result in inflammation. As inflammation subsides, growth processes can resume, and the horse can begin to heal itself. With the help of proper podiatry and continuing care, the horse will recover.

However, Laminil cannot be effective unless the stressor that initiated the laminitis episode has been positively identified and completely removed from the horse’s environment where possible.

Identifying the stressor can be difficult because the clinical signs of laminitis do not appear until 72-96 hours after initial exposure to the stressor. To identify the stressor entails thinking back to what changes occurred in the horse’s life three or four days before the clinical signs appeared.

A laminitis stressor can be a biological agent, environmental condition, or other external stimulus that causes stress to the animal. The animal responds to the stressor as a threat, which elicits the flight-or-fight immune system response that starts the laminitis cascade.

Laminitis stressors include grain overload, grass founder, equine metabolic syndrome, insulin resistance, colic, Cushings, Potomac Fever, retained placenta, steroids, vaccinations, concussion from work on hard ground, a long trailer ride, and accident.

In cases of grain, grass, and other environmental conditions, the stressor must be removed completely and immediately. The immune response and laminitis cascade will continue as long as the animal is exposed to the stressor, regardless of the quantity of exposure. Reducing the amount of the stressor will not stop the cascade.

In cases of hay laminitis where there has been no change in diet, the animal may have received too much forage and might be diagnosed as Equine Metabolic Syndrome or EMS, which is associated with obesity. Just reducing the amount of the same hay will not stop the laminitis process. The current hay has to be stopped immediately and completely. A different hay can be given in reduced amount.