The first effective treatment for the second leading cause of death in horses.
Laminil™ is a mast cell stabilizing drug in topical cream and sterile solution that halts the inflammatory response to stress leading to laminitis — changing the paradigm of equine care.
"The inflammatory mediators elevated in laminitis are produced and distributed by mast cells — the same as in other systemic inflammatory disorders."
Laminitis is a painful and debilitating inflammatory response expressed in the feet of horses. The traditional view treated it as a foot condition — but research reveals it is a systemic immune disorder driven by mast cell dysregulation.
Mast cells are multi-functional immune cells found in all vascularized tissue. When over-activated by local and systemic stress, mast cells release inflammatory mediators that degrade connective tissue in the feet, leading to the pain and damage of laminitis.
Studies of horses with laminitis find two-fold increases in mast cell number and activation compared to healthy horses, along with elevated cytokines and inflammatory mediators — confirming the mast cell activation model.
GI tract, feet (digits), eyes, and skin are all affected — confirming systemic mast cell involvement.
Studies find higher mast cell density and elevated inflammatory mediators in lamellar tissue of horses with laminitis.
Mast cells regulate vascularity, wound healing, homeostasis, and defense against infection. Over-activation disrupts all of these.
By blocking aberrant mast cell activation, Laminil halts the inflammatory cascade and restores vital function.
Laminil products are made by certified compounding pharmacies and are available by veterinary prescription. Products are shipped via UPS and USPS in the USA and FedEx internationally.
Laminil Cream applied to the coronary band, heel bulbs, and frog puts Laminil into circulation throughout the foot. It stabilizes mast cells in connective tissue, restores vascular function, improves blood flow, and promotes healthy hoof growth.
Laminil Cream promotes hoof growth by halting mast cell activation, opening growth receptors, and enabling healthy hoof development. Hoof growth typically increases by 30% in 60 days.
Laminil Solution is designed for intra-muscular (IM), intravenous (IV), and intra-articular (IA) injection. One vial is sufficient for two limb perfusions or one IM loading series.
The IM Loading Series of 12 injections in 30 days stabilizes mast cells, mitigates inflammation, resets the immune system, restores vital functions, and addresses underlying systemic inflammatory conditions.
The active pharmaceutical ingredient in Laminil, cromolyn sodium, is an FDA-approved mast cell stabilizing drug used for treatment of allergies, asthma, and other mast cell disorders in humans — repurposed with precision for equine care.
Cromolyn is considered the "gold standard" for mast cell stabilizers and is used in scientific experiments worldwide to identify the role of mast cells in various inflammatory diseases.
The herbal origin of cromolyn traces to ancient Egypt — Dr. Roger Altounyan discovered it in 1965 after studying Ammi visnaga (khella), a muscle relaxant used since ancient times. His discovery launched an entirely new class of compounds.
U.S. Patent 9132116 | EU Patent 2424527Laminil can be used prophylactically and therapeutically across all stages of laminitis. Select a condition below to see the appropriate treatment approach.
Horses with developmental laminitis have over twice the number and activity of mast cells as healthy horses. Pre-treatment with Laminil Cream and IM injections prevents aberrant mast cell activation and acute inflammatory episodes.
Mast cells play central roles in insulin dysregulation, obesity, GI tract disorders, and metabolic syndrome — all conditions that set the stage for laminitis. Early intervention is the most effective strategy.
Laminitis episodes can be prevented when expected. Treatment should begin before acute symptoms appear and before triggering events such as severe weather, a long trailer ride, or hard work on hard ground.
In some cases, Laminil Cream alone prevents an episode. In others, the IM Cluster is effective. Combined, they offer the most robust protection for chronically vulnerable horses.
In a limb perfusion, a tourniquet is fastened above the knee or fetlock and Laminil Solution is injected into the vein below. Laminil perfuses the lamellar connective tissue, blocks mast cell activation, and stops the inflammatory cascade at the source.
The symptoms of acute laminitis — heat in the feet and pounding digital pulse — subside in the first hour after Laminil perfusions. Immediate icing (cryotherapy) while preparing for treatment is also recommended.
Mast cells are abundant in the synovial lining. Aberrant activation of synovial mast cells produces MMP-9, IL-6, and other mediators that degrade the synovial membrane. Laminil stabilizes these mast cells and prevents the inflammatory response to routine procedures.
Fifty milligrams of Laminil added to a corticosteroid injection can prevent an unlikely but tragic inflammatory response to a routine joint procedure.
Stress of air and ground transport and quarantine can induce laminitis in perfectly fit horses. Hard work on hard ground, severe weather, farrier visits, and injury all present inflammatory risk. Proactive Laminil treatment prevents these episodes.
For supporting-limb or surgery-related laminitis, IM injections begin as soon as possible after the initiating injury and continue through surgery and recovery.
Having been in healthcare myself for 35 years, it takes a lot to impress me. But Laminil has done exactly that. To see a dead lame animal begin walking comfortably is nothing less than a miracle.
Vet and farrier were out yesterday to re-radiograph, and she has zero rotation and is completely sound. Absolutely can't thank you enough. It truly is an incredible product!
I applied Laminil cream, rubbed it in, and rewrapped the hock. The next day, the swelling was all but gone.
The results produced by using Laminil Cream are fantastic, and I highly recommend its use for any sort of inflammatory hoof condition.
The horse's hoof transformed itself with more heel and better palmar angles, thicker walls and thicker soles, a healthy hoof. This cream works like nothing I've seen.
I'm a skeptic when it comes to new drugs for horses, but this Laminil drug is a life-saver.
Apply Laminil Cream to the coronary band and heel bulbs. Use a dime-size dab at each application point and massage gently.
Gloves are recommended as standard procedure. However, Laminil is not toxic and is used to treat human arthritis and inflammation. Please send feedback and questions to JohnKelly970@gmail.com.
| Condition | Frequency |
|---|---|
| Acute laminitis — front feet | Twice daily |
| Acute laminitis — all four feet | Daily |
| Prevention / maintenance | Twice per week |
| Spring pasture grazing season | Daily |
| Before surgery (supporting limb) | All four feet |
| After the farrier / transport / hard work | Single application |
| Retarded hoof growth | Daily for 60 days |
| Arthritic joints / injured tendons | Daily until resolved |
12 injections in 30 days on days:
1, 2, 3, 5, 7, 9, 12, 15, 18, 22, 26, 30
Maintenance dose is 2–3 injections per week for as long as response is positive. For mules and donkeys, multiply equine dosage by 1.5 to increase dose by 50%.
Every minute of every day, thousands of horses around the world endure the pain and suffering of laminitis. It takes the lives of tens of thousands of horses every year — it is the second leading medical cause of death.
Yet there has been no effective treatment for laminitis, until now. Laminil stops the inflammatory response and opens a window of opportunity for the horse to heal and recover. Our mission is to relieve the pain and suffering by making Laminil available to horses everywhere.
Laminitis does not have to be a death sentence. With proper podiatry, well-managed care, and Laminil treatments, horses can recover.
Dr. Kelly is a scientist, historian, and horseman who is dedicated to relieving the suffering of horses. Since 2016, he has been focused on the role of mast cells in immune system disorders and works with immunologists at leading research institutions around the world.
He is a 3-day eventer and works with the racing community to rehabilitate and repurpose off-the-track thoroughbreds.
A privately-held equine pharmaceutical company that develops innovative and effective treatments for horses. Laminil is the first effective treatment for laminitis. Future products will be similarly innovative in treating common equine ailments.
Laminil products are available by veterinary prescription from certified compounding pharmacies. Contact us to learn more or place an order.
Laminil products require veterinary prescription. Payment via PayPal. Shipped via UPS and USPS in USA and FedEx internationally.
JohnKelly970@gmail.comYour experience helps other horses and their owners. Please send testimonials and before/after videos — they are posted on the website to help others decide if Laminil can help their horses.
Submit a Testimonial